August 28, 2014
6 FLI-Teams beim 2. Firmenstaffel-Triathlon 2014 » more

June 27, 2014
Steffen Mayerl mit Promotionspreis 2014 der FSU Jena ausgezeichnet » more

June 24, 2014
Tag der Architektur am 28. und 29. Juni » more

  » Overview News

Press Releases

September 18, 2014
Glucose substitution prolongs lifespan of old mice with short telomeres » more

August 14, 2014
Neuer Mechanismus der Krebsentstehung „Jungbrunnenenzym“ kurbelt Ribosomenproduktion an (Uni Ulm) » more

August 13, 2014
Telomerase – Ein Enzym mit zwei Gesichtern » more

  » Overview Press Releases


Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is


«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».


LFVDoes a healthy way of living in the later phase of our live influences our cognitive performance? How does a balanced nutrition affect the health costs of seniors? Is the ageing process influenced more by genetic or by external factors? These are just a few questions the interdisciplinary Leibniz Research Alliance Healthy Ageing (LRA Healthy Ageing) will focus on during the next years. 20 institutes from all sections of the Leibniz Association have signed the collaboration contract. Prof. Dr. K. Lenhard Rudolph, scientific director of FLI, and Prof. Jean Krutmann (IUF) act as speakers of the Research Alliance. A dedicated website provides information about all activities and research projects of the LRA Healthy Ageing.
>> Press release 24.06.2014


Recent Selected Publications

Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions
Gonzalez OG, Assfalg R, Koch S, Schelling A, Meena JK, Kraus J, Lechel A, Katz SF, Benes V, Scharffetter-Kochanek K, Kestler HA, Günes C*, Iben S*
Nat Commun. 2014, 5, 4599 [PubMed]


Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons
Szafranski K, Fritsch C, Schumann F, Siebel L, Sinha R, Hampe J, Hiller M, Englert C, Huse K, Platzer M
Nucleic Acids Res 2014 (epub ahead of print) [PubMed]


RepARK--de novo creation of repeat libraries from whole-genome NGS reads
Koch P, Platzer M, Downie BR
Nucleic Acids Res. 2014, 42, e80 [PubMed]


Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions
Tapias A, Zhou ZW, Shi Y, Chong Z, Wang P, Groth M, Platzer M, Huttner W, Herceg Z, Yang YG, Wang ZQ
Cell Stem Cell. 2014, 14, 632-643 [PubMed]


Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength
Bentzinger CF*, von Maltzahn J*, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison DD, Rudnicki MA
J Cell Biol. 2014, 205, 97-111 [PubMed]


» Overview Publications