September 25, 2014
Schüler der Jenaplan-Schule am FLI » more

September 15, 2014
2. Gesundheitstag am FLI » more

September 1, 2014
Lars Björn Riecken erhält FENS-IBRO Stipendium » more

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Press Releases

October 20, 2014
Diabetes - Gehirn beeinflusst den Energie- und Stoffwechselhaushalt » more

September 30, 2014
Telomere und Telomerase: Nobelpreisträgerin am Leibniz-Institut für Altersforschung zu Gast » more

September 18, 2014
Glucose substitution prolongs lifespan of old mice with short telomeres » more

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Our Mission

The aging of living organisms is a process involving multiple factors, one which is influenced by environmental and genetic factors. Our main task is to understand the molecular mechanisms that underlie the human aging process and lead to age-related diseases. We hope that this knowledge can contribute to improve health in aging human. The main question we are trying answer:


«What molecular mechanisms and genetic factors contribute to the development of cellular and organism dysfunction in the course of human aging, and how can these be therapeutically influenced?».


LFVDoes a healthy way of living in the later phase of our live influences our cognitive performance? How does a balanced nutrition affect the health costs of seniors? Is the ageing process influenced more by genetic or by external factors? These are just a few questions the interdisciplinary Leibniz Research Alliance Healthy Ageing (LRA Healthy Ageing) will focus on during the next years. 20 institutes from all sections of the Leibniz Association have signed the collaboration contract. Prof. Dr. K. Lenhard Rudolph, scientific director of FLI, and Prof. Jean Krutmann (IUF) act as speakers of the Research Alliance. A dedicated website provides information about all activities and research projects of the LRA Healthy Ageing.
>> Press release 24.06.2014


Recent Selected Publications

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, Sim JC, Smith KR, Oehler J, Cabrera E, Freire R, Pope K, Nahid A, Norris F, Leventer RJ, Delatycki MB, Barbi G, von Ameln S, Högel J, Degoricija M, Fertig R, Burkhalter MD, Hofmann K, Thiele H, Altmüller J, Nürnberg G, Nürnberg P, Bahlo M, Martin GM, Aalfs CM, Oshima J, Terzic J, Amor DJ, Dikic I, Ramadan K, Kubisch C.
Nat Genet. 2014 (epub ahead of print) [PubMed]


Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions
Gonzalez OG, Assfalg R, Koch S, Schelling A, Meena JK, Kraus J, Lechel A, Katz SF, Benes V, Scharffetter-Kochanek K, Kestler HA, Günes C*, Iben S*
Nat Commun. 2014, 5, 4599 [PubMed]


Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons
Szafranski K, Fritsch C, Schumann F, Siebel L, Sinha R, Hampe J, Hiller M, Englert C, Huse K, Platzer M
Nucleic Acids Res 2014 (epub ahead of print) [PubMed]


RepARK--de novo creation of repeat libraries from whole-genome NGS reads
Koch P, Platzer M, Downie BR
Nucleic Acids Res. 2014, 42, e80 [PubMed]


Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions
Tapias A, Zhou ZW, Shi Y, Chong Z, Wang P, Groth M, Platzer M, Huttner W, Herceg Z, Yang YG, Wang ZQ
Cell Stem Cell. 2014, 14, 632-643 [PubMed]


» Overview Publications