Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

«What are the mechanisms that induce senescence or that cause the development of diseases related to age?».

Recent Selected Publications

Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells upon combined TNFR1/LTβR NF-κB signaling
Lötzer K, Döpping S, Connert S, Gräbner R, Spanbroek R, Lemser B, Beer M, Hildner M, Hehlgans T, van der Wall M, Mebius RE, Lovas A, Randolph GJ, Weih F*, Habenicht AJR *
Arterioscler Thromb Vasc Biol 2009, 30, 395-402 *equal contribution

 

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.
Friedrich RP, Tepper K, Rönicke R, Soom M, Westermann M, Reymann K, Kaether C, Fändrich M
Proc.Natl.Acad.Sci.USA 2010, epub ahead of print January 19

 

Nucleolar retention of a translational C/EBPα isoform stimulates rDNA transcription and cell size
Müller C, Bremer A, Schreiber S, Eichwald S, Calkhoven CF
EMBO Journal 2010, epub ahead of print January 19

 

C/EBPβ^ΔuORFmice—a genetic model for uORF-mediated translational control in mammals
Wethmar K, Begay V, Smink JJ, Zaragoza K, Wiesenthal V, Dörken B, Calkhoven CF, Leutz A
Genes & Development 2010, 24, 15-20

 

Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling
Lindner I, Hemdan NY, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, Hollborn M, Thal D, Gebhardt R, Birkenmeier G
Cancer Research 2010, 70, 277-87

 

» Overview Publications