News

March 15, 2014
FLI-Ausbildung beim 21. Berufs-Informations-Markt in Jena vorgestellt » more

February 12, 2014
"Forsche Schüler Tag" am FLI » more

December 31, 2013
Ronny Hänold gewinnt "autoMACSpro award 2013" » more

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Press Releases

April 10, 2014
Älter dank Nahrungsergänzungsmittel - Glukosamin verlängert das Leben im Tierversuch (FLI / HKI) » more

April 3, 2014
7th BioVaria to Take Place in Munich on 6 May 2014 (Ascenion) » more

April 2, 2014
Schilddrüsenhormone für Gehirnfunktion essentiell » more

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Our Mission

Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

 

«What are the molecular mechanisms and genetic factors contributing to the evolution of cellular and organismal dysfunction during human aging?».

 

Recent Selected Publications


D-Glucosamine supplementation extends life span of nematodes and of ageing mice
Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M
Nat Commun. 2014, 5, 3563 [PubMed]

 

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H
J Clin Invest. 2014, [epub ahead of print] [PubMed]

 

Impact of genomic damage and ageing on stem cell function
Behrens A, van Deursen JM, Rudolph KL, Schumacher B
Nat Cell Biol. 2014, 16, 201-207 [PubMed]

 

Gadd45a regulates hematopoietic stem cell stress responses in mice
Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z
Blood. 2014, 123, 851-862 [PubMed]

 

Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling
Schulz A, Kyselyova A, Baader SL, Jung MJ, Zoch A, Mautner VF, Hagel C, Morrison H
Brain. 2014, 137, 420-432 [PubMed]

 

» Overview Publications