Platzer Laboratory

Genome analysis

Genomics of complex diseases, ageing and model organisms

With clinical partners, we work on detection and functional analyses of genetic & epigenetic variations determining the individual susceptibility to complex disorders (adiposity, cancer, inflammation) and ageing. We are engaged in the sequence analysis of eukaryotic model organisms, prokaryotic genomes and metagenomes.

Projects (selected)

» The "genealogical tree" of Ernst Haeckel (1874).

Towards a novel model for ageing research: genome analysis of the short-lived seasonal fish Nothobranchius furzeri (WGL-Pakt) » more
Impact of genomic variations and DNA methylation on human longevity (more) and obesity (LGSA)
Copy-number and sequence variations of defensin genes in cancer (Wilhelm-Sander-Stiftung) and inflammation
Genetic predisposition to environmental disorders, like Crohn's disease/ulcerative colitis and sarcoidosis (NGFN) » more
Alternative splicing as an evolutionary process to increase proteome plasticity (DFG) and as a modulator of signal transduction (SFB604)
From comparative to functional genomics of social amoeba (DFG) » more
Functional genome analysis of pathogenic dermatophytes (WGL-Pakt) » more
Exploring the barley genome: anchoring the physical map by explorative genomic sequencing (BARLEX)

Recent selected publications

Siddiqui R A, Sauermann U, Altmuller J, Fritzer E, Nothnagel M, Dalibor N, Fellay J, Kaup F J, Stahl-Hennig C, Nurnberg P, Krawczak M, Platzer M. (2009) X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. Am J Hum Genet 2009, 85, 228-239 [PubMed]
Reichwald K, Lauber C, Nanda I, Kirschner J, Hartmann N, Schories S, Gausmann U, Taudien S, Schilhabel M B, Szafranski K, Glockner G, Schmid M, Cellerino A, Schartl M, Englert C, Platzer M (2009) High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research. Genome Biol. 10, R16.[PubMed]
Heidel AJ, Glöckner G (2008) Mitochondrial genome evolution in the social amoebae. Mol Biol Evol. 25, 1440-1450. [PubMed]
Hiller M, Platzer M (2008) Widespread and subtle: alternative splicing at short-distance tandem sites. Trends Genet. 24, 246-255. [PubMed]
Nguyen T, Ishida K, Jenke-Kodama H, Dittmann E, Gurgui C, Hochmuth T, Taudien S, Platzer M, Hertweck C, Piel J (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat Biotechnol. 26, 225-233. [PubMed]

Last update: August 21, 2009

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