Human ageing is a multifactorial process controlled by both environmental and genetic factors. Our mission is to understand the molecular mechanisms that underlie the ageing process and that lead to age-related diseases. We hope that eventually this knowledge can contribute to a more healthy ageing of people. The central question we are aiming at answering is

«What are the mechanisms that induce senescence or that cause the development of diseases related to age?».

Recent Selected Publications

Transcriptional repression of ATF4 by C/EBPβ differentially regulates the integrated stress response
Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC
J Biol Chem. 2012, May 3, 2012, doi: 10.1074/jbc.M112.351783 Journal

 

Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Vandevyver S, Dejager L, Van Bogaert T, Kleyman A, Liu Y, Tuckermann J, Libert C
J Clin Invest. 2012, epub ahead of print [PubMed]

 

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M
Cell Metab. 2012, 15, 451-465 [PubMed]

 

Fungal-induced cell cycle impairment, chromosome instability and apoptosis via differential activation of NF-κB
Ben-Abdallah M, Sturny-Leclère A, Avé P, Louise A, Moyrand F, Weih F, Janbon G, Mémet S
PLoS Pathog. 2012, 8, e1002555 [PubMed]

 

Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV1.4
Tietze AA, Tietze D, Ohlenschläger O, Leipold E, Ullrich F, Kühl T, Mischo A, Buntkowsky G, Görlach M, Heinemann SH, Imhof D
Angew Chem Int Ed Engl. 2012, 51, 4058-4061 [PubMed]

 

» Overview Publications