Mission

The Jena Centre for Bioinformatics (JCB) has a mission to promote inter-disciplinary research and to establish training courses in bioinformatics in the Jena region.
The research projects are primarily focused on

Molecular Communication Processes in Normal and Pathological Cellular States.
NMR structure
GenColors

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Fuzzy
The Görlach Group at the FLI has solved the structure of the partially folded high-risk HPV 45 oncoprotein E7.

Ohlenschläger, O. et al., Solution structure of the partially folded high-risk HPV 45 oncoprotein E7. Oncogene 2006, 25, 5953-5959. [PubMed]
Novel tools for accelerated comparative analysis and annotation of prokaryotic genomes were developed by the Platzer and Sühnel Groups at the FLI.

Romualdi, A. et al.; GenColors: annotation and comparative genomics of prokaryotes made easy. In: Comparative Genomics - Volume I (N. Bergman, Ed.), Methods in Molecular Biology, Humana Press, Totowa/NJ, 2007, ISBN: 978-1-58829-693-1. [PubMed]
Romualdi, A. et al.; GenColors: accelerated comparative analysis and annotation of prokaryotic genomes at various stages of completeness. Bioinformatics 2005, 21, 3669-3672. [PubMed]
Gene expression based classification of rheumatoid arthritis (RA), osteoarthritis (OA) adopting fuzzy cluster and rule-based methods. Experimental data were provided by the Kinne Group at the FSU. The analysis was done by the company BioControl Jena GmbH and by the Guthke Group at the HKI.

Hoffmann, M. et al.; Robust computational reconstitution - a new method for the comparative analysis of gene expression in tissues and isolated cell fractions. BMC Bioinformatics 2006, 7, 369. [PubMed]
Töpfer, S. et al.; The NetGenerator algorithm: reconstruction of gene regulatory networks. Lecture Notes Bioinformatics 2007, 4366, 119-130.

  See further examples of the work of JCB members at the archived start pages.