Ausgewählte Publikationen
(letzter 5-Jahres-Impact-Faktor größer 7; in chronologischer Reihenfolge)

 

Physiological state co-regulates thousands of mammalian mRNA splicing events at tandem splice sites and alternative exons

Szafranski K, Fritsch C, Schumann F, Siebel L, Sinha R, Hampe J, Hiller M, Englert C, Huse K, Platzer M

Nucleic Acids Res 2014 (epub ahead of print) [PubMed]


RepARK--de novo creation of repeat libraries from whole-genome NGS reads

Koch P, Platzer M, Downie BR

Nucleic Acids Res. 2014, 42, e80 [PubMed]


Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions

Tapias A, Zhou ZW, Shi Y, Chong Z, Wang P, Groth M, Platzer M, Huttner W, Herceg Z, Yang YG, Wang ZQ

Cell Stem Cell. 2014, 14, 632-643 [PubMed]


Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength

Bentzinger CF*, von Maltzahn J*, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison DD, Rudnicki MA

J Cell Biol. 2014, 205, 97-111 [PubMed]

(*shared first authorship)

A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells

Braig M, Pällmann N, Preukschas M, Steinemann D, Hofmann W, Gompf A, Streichert T, Braunschweig T, Copland M, Rudolph KL, Bokemeyer C, Koschmieder S, Schuppert A, Balabanov S, Brümmendorf TH

Leukemia. 2014 (epub ahead of print) [PubMed]


Expression of the lymphoid enhancer factor 1 is required for normal hematopoietic stem and progenitor cell function

Edmaier KE, Stahnke K, Vegi N, Mulaw M, Ihme S, Scheffold A, Rudolph KL, Buske C

Leukemia. 2014, 28, 227-230 [PubMed]


Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer

Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, Rudolph KL, Sharpless NE, Muss HB

J Natl Cancer Inst. 2014, 106, dju057 [PubMed]


Biosimilar G-CSF based mobilization of peripheral blood hematopoietic stem cells for autologous and allogeneic stem cell transplantation

Schmitt M, Publicover A, Orchard KH, Görlach M, Wang L, Schmitt A, Mani J, Tsirigotis P, Kuriakose R, Nagler A

Theranostics. 2014, 4, 280-289 [PubMed]


Aging stem cells: transcriptome meets epigenome meets methylome

Tümpel S, Rudolph KL

Cell Stem Cell. 2014, 14, 551-552 [PubMed]


Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis

Mohanta SK*, Yin C*, Peng L, Srikakulapu P, Bontha V, Hu D, Weih F, Weber C, Gerdes N, Habenicht AJ

Circ Res. 2014, 114, 1772-1787 [PubMed]

(*shared first authorship)

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M

Nat Commun. 2014, 5, 3563 [PubMed]


Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H

J Clin Invest. 2014 (epub ahead of print) [PubMed]


Impact of genomic damage and ageing on stem cell function

Behrens A, van Deursen JM, Rudolph KL, Schumacher B

Nat Cell Biol. 2014, 16, 201-207 [PubMed]

(based on the Else Kröner-Fresenius-Symposium in Molecular Medicine)

Gadd45a regulates hematopoietic stem cell stress responses in mice

Chen Y, Ma X, Zhang M, Wang X, Wang C, Wang H, Guo P, Yuan W, Rudolph KL, Zhan Q, Ju Z

Blood. 2014, 123, 851-862 [PubMed]


Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling

Schulz A*, Kyselyova A*, Baader SL, Jung MJ, Zoch A, Mautner VF, Hagel C*, Morrison H*

Brain. 2014, 137, 420-432 [PubMed]

(*shared first and senior authorships)

DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding

Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H, Grosse F

Nucleic Acids Res. 2014, 42, 2308-2319 [PubMed]


Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3

Kornak U, Mademan I, Schinke M, Voigt M, Krawitz P, Hecht J, Barvencik F, Schinke T, Gießelmann S, Beil, FT, Pou-Serradell A, Vílchez JJ, Beetz C, Deconinck T, Timmerman V, Kaether C, De Jonghe P, Hübner CA, Gal A, Amling M, Mundlos S, Baets J, Kurth I

Brain. 2014, 137, 683-692 [PubMed]


The essential function of the MRN complex in the resolution of endogenous replication intermediates

Bruhn C, Zhou ZW, Ai H, Wang ZQ

Cell Rep. 2014, 6, 182-195 [PubMed]


The genome of the foraminiferan Reticulomyxa filosa

Glöckner G, Hülsmann N, Schleicher M, Noegel AA, Eichinger L, Gallinger C, Pawlowski J, Sierra R, Euteneuer U, Pillet L, Moustafa A, Platzer M, Groth M, Szafranski K, Schliwa M

Curr Biol. 2014, 24, 11-18 [PubMed]


Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells

Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z, Gao S

Cell Stem Cell. 2014, 14, 27-39 [PubMed]


AgeFactDB - the JenAge Ageing Factor Database - towards data integration in ageing research

Hühne R, Thalheim T, Sühnel J

Nucleic Acids Res. 2014, 42, D892-D896 [PubMed]


A sequence-ready physical map of barley anchored genetically by two million SNPs

Ariyadasa R, Mascher M, Nussbaumer T, Schulte D, Frenkel Z, Poursarebani N, Zhou R, Steuernagel B, Gundlach H, Taudien S, Felder M, Platzer M, Himmelbach A, Schmutzer T, Hedley P, Muehlbauer G, Scholz U, Korol A, Mayer K, Waugh R, Langridge P, Graner A, Stein N

Plant Physiol. 2014, 164, 412-423 [PubMed]


Lin28a - boost your energy for youthful regeneration

Burkhalter MD, Morita Y, Rudolph KL

EMBO J. 2014, 33, 5-6 [PubMed]


Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation

Min W, Bruhn C, Grigaravicius P, Zhou ZW, Li F, Krüger A, Siddeek B, Greulich KO, Popp O, Meisezahl C, Calkhoven CF, Bürkle A, Xu X, Wang ZQ.

Nat Commun. 2013, 4, 2993 [PubMed]


Regulation of Son of sevenless by the membrane-actin linker protein ezrin

Geißler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H

Proc Natl Acad Sci USA. 2013, 110, 20587-20592 [PubMed]


Heterozygous mutations in PALB2 cause DNA replication and damage response defects

Nikkilä J, Christin Parplys A, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R

Nat Commun. 2013, 4, 2578 [PubMed]


The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes

Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S

Brain Struct Funct. 2013 (epub ahead of print) [PubMed]


p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury

Marhenke S, Buitrago-Molina LE, Endig J, Orlik J, Schweitzer N, Klett S, Longerich T, Geffers R, Sánchez Muñoz A, Dorrell C, Katz SF, Lechel A, Weng H, Krech T, Lehmann U, Dooley S, Rudolph KL, Manns MP, Vogel A

Gut. 2013 (epub ahead of print) [PubMed]


Heme impairs the ball-and-chain inactivation of potassium channels

Sahoo N, Goradia N, Ohlenschläger O, Schönherr R, Friedrich M, Plass W, Kappl R, Hoshi T, Heinemann SH

Proc Natl Acad Sci USA. 2013, 110, E4036-E4044 [PubMed]


Small molecules intercept Notch signaling and the early secretory pathway

Krämer A, Mentrup T, Kleizen B, Rivera-Milla E, Reichenbach D, Enzensperger C, Nohl R, Täuscher E, Görls H, Ploubidou A, Englert C, Werz O, Arndt HD, Kaether C

Nat Chem Biol. 2013, 9, 731-738 [PubMed]


Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.

Nat Chem Biol. 2013, 9, 693-700 [PubMed]


PARP-1 regulates expression of TGF-β receptors in T cells

Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel JE, Maruyama T, Wei G, Abbatiello B, Wang ZQ, Zhao K, Chen W

Blood. 2013, 122, 2224-2232 [PubMed]


Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells

Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H

Cell 2013, 154, 1112-1126 [PubMed]


LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys

Burghardt T, Kastner J, Suleiman H, Rivera-Milla E, Stepanova N, Lottaz C, Kubitza M, Böger CA, Schmidt S, Gorski M, de Vries U, Schmidt H, Hertting I, Kopp J, Rascle A, Moser M, Heid IM, Warth R, Spang R, Wegener J, Mierke CT, Englert C, Witzgall R

J Am Soc Nephrol 2013, 24, 1830-1848 [PubMed]


The responsibility of the scientist. What can history teach us about how scientists should handle research that has the potential to create harm?

Herrlich P

EMBO Rep. 2013, 14, 759-764 [PubMed]


Grk5l controls heart development by limiting mTOR signaling during symmetry breaking

Burkhalter MD, Fralish GB, Premont RT, Caron MG, Philipp M

Cell Rep. 2013, 4, 625-632 [PubMed]


An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence

Zhou ZW, Liu C, Li TL, Bruhn C, Krueger A, Min W, Wang ZQ, Carr AM

PLoS Genet. 2013, 9, e1003702 [PubMed]


Pan genome of the phytoplankton Emiliania underpins its global distribution

Read BA, Kegel J, Klute MJ, Kuo A, Lefebvre SC, Maumus F, Mayer C, Miller J, Monier A, Salamov A, Young J, Aguilar M, Claverie JM, Frickenhaus S, Gonzalez K, Herman EK, Lin YC, Napier J, Ogata H, Sarno AF, Shmutz J, Schroeder D, de Vargas C, Verret F, von Dassow P, Valentin K, Van de Peer Y, Wheeler G; Emiliania huxleyi Annotation Consortium, Dacks JB, Delwiche CF, Dyhrman ST, Glöckner G, John U, Richards T, Worden AZ, Zhang X, Grigoriev IV

Nature. 2013, 499, 209-213 [PubMed]


Distribution, functional impact, and origin mechanisms of copy number variation in the barley genome

Muñoz-Amatriaín M, Eichten SR, Wicker T, Richmond TA, Mascher M, Steuernagel B, Scholz U, Ariyadasa R, Spannagl M, Nussbaumer T, Mayer KF, Taudien S, Platzer M, Jeddeloh JA, Springer NM, Muehlbauer GJ, Stein N

Genome Biol. 2013, 14, R58 [PubMed]


Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

Dang M, Armbruster N, Miller MA, Cermeno E, Hartmann M, Bell GW, Root DE, Lauffenburger DA, Lodish HF, Herrlich A

Proc Natl Acad Sci USA. 2013, 110, 9776-9781 [PubMed]

EDITORS' CHOICE by Wei Wong "Cell Biology - Specifying Substrate Specificity (Sci. Signal. 2013, Vol. 6, Issue 280, p. ec140"

Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus

von Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, Erhart W, von Schönfels W, Egberts J, Seeger M, Arlt A, Balschun T, Franke A, Lerch MM, Mayerle J, Kratzer W, Boehm BO, Huse K, Schniewind B, Tiemann K, Jiang ZY, Han TQ, Mittal B, Srivastava A, Fenger M, Jørgensen T, Schirin-Sokhan R, Tönjes A, Wittenburg H, Stumvoll M, Kalthoff H, Lammert F, Tepel J, Puschel K, Becker T, Schreiber S, Platzer M, Völzke H, Krawczak M, Miquel JF, Schafmayer C, Hampe J.

Hepatology. 2013, 57, 2407-2417 [PubMed]


Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension

Schmeisser S, Schmeisser K, Weimer S, Groth M, Priebe S, Fazius E, Kuhlow D, Pick D, Einax JW, Guthke R, Platzer M, Zarse K, Ristow M

Aging Cell. 2013, 12, 508-517 [PubMed]


RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model

Mills JR, Malina A, Lee T, Di Paola D, Larsson O, Miething C, Grosse F, Tang H, Zannis-Hadjopoulos M, Lowe SW, Pelletier J

Blood. 2013, 121, 3402-3412 [PubMed]


PPARβ/δ governs Wnt signaling and bone turnover

Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G

Nat Med. 2013, 19, 608-613 [PubMed]


Telomere stability--Wnt it or lose it

Bauer K, Tao S, Rudolph KL

EMBO Rep. 2013, 14, 297-298 [PubMed]


Histone acetyltransferase cofactor trrap maintains self-renewal and restricts differentiation of embryonic stem cells

Sawan C, Hernandez-Vargas H, Murr R, Lopez F, Vaissière T, Ghantous AY, Cuenin C, Imbert J, Wang ZQ, Ren B, Herceg Z

Stem Cells. 2013, 31, 979-991 [PubMed]


Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1

Gebeshuber CA, Kornauth C, Dong L, Sierig R, Seibler J, Reiss M, Tauber S, Bilban M, Wang S, Kain R, Böhmig GA, Moeller MJ, Gröne HJ, Englert C, Martinez J, Kerjaschki D

Nat Med. 2013, 19, 481-487 [PubMed]


Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy

Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schröder JM, Gutmann DH, Giovannini M, Morrison H

Nat Neurosci. 2013, 16, 426-433 [PubMed]


Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding

Koeberle A, Shindou H, Koeberle SC, Laufer SA, Shimizu T, Werz O

Proc Natl Acad Sci USA. 2013, 110, 2546-2551 [PubMed]


The role of telomeres in stem cells and cancer

Günes C, Rudolph KL

Cell. 2013, 152, 390-393 [PubMed]


The holocentric species Luzula elegans shows interplay between centromere and large-scale genome organization

Heckmann S, Macas J, Kumke K, Fuchs J, Schubert V, Ma L, Novák P, Neumann P, Taudien S, Platzer M, Houben A

Plant J. 2013, 73, 555-565 [PubMed]


Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

Schwitalla S, Ziegler PK, Horst D, Becker V, Kerle I, Begus-Nahrmann Y, Lechel A, Rudolph KL, Langer R, Slotta-Huspenina J, Bader FG, Prazeres da Costa O, Neurath MF, Meining A, Kirchner T, Greten FR

Cancer Cell. 2013, 23, 93-106 [PubMed]


Who decides when to cleave an ectodomain?

Hartmann M, Herrlich A, Herrlich P

Trends Biochem Sci. 2013, 38, 111-120 [PubMed]


Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR

Hum Mol Genet. 2013, 22, 262-270 [PubMed]


Localization and orientation of heavy atom cluster compounds in protein crystals using molecular replacement

Dahms SO, Kuester M, Streb C, Roth C, Sträter N, Than ME

Acta Crystallogr D Biol Crystallogr, 2013, 69, 284-297 [PubMed]


GenColors-based comparative genome databases for small eukaryotic genomes

Felder M, Romualdi A, Petzold A, Platzer M, Sühnel J, Glöckner G

Nucleic Acids Res. 2013, 41, D692-D699 [PubMed]


Competition between NBS1 and ATMIN controls ATM signaling pathway choice

Zhang T, Penicud K, Bruhn C, Loizou JI, Kanu N, Wang ZQ, Behrens A

Cell Rep. 2012, 2, 1498-1504 [PubMed]


Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo

Lee MK, Teoh WW, Phang BH, Tong WM, Wang ZQ, Sabapathy K

Cancer Cell. 2012, 22, 751-764 [PubMed]


The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1

Haag N, Schwintzer L, Ahuja R, Koch N, Grimm J, Heuer H, Qualmann B, Kessels MM

J Neurosci 2012, 32, 17842-17856 [PubMed]


Functionality, growth and accelerated aging of tissue engineered living autologous vascular grafts

Kelm JM, Emmert MY, Zürcher A, Schmidt D, Begus Nahrmann Y, Rudolph KL, Weber B, Brokopp CE, Frauenfelder T, Leschka S, Odermatt B, Jenni R, Falk V, Zünd G, Hoerstrup SP

Biomaterials. 2012, 33, 8277-8285 [PubMed]


VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis

Thiele W, Krishnan J, Rothley M, Weih D, Plaumann D, Kuch V, Quagliata L, Weich HA, Sleeman JP

Blood. 2012, 120, 1899-1907 [PubMed]


The multiple facets of glucocorticoid action in rheumatoid arthritis

Baschant U, Lane NE, Tuckermann J

Nat Rev Rheumatol. 2012, 8, 645-655 [PubMed]


A physical, genetic and functional sequence assembly of the barley genome

The International Barley Genome Sequencing Consortium

Nature. 2012, 491, 711-716 [PubMed]


PML promotes MHC class II gene expression by stabilizing the class II transactivator

Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P

J Cell Biol. 2012, 199, 49-63 [PubMed]


Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting

Fritsch C, Herrmann A, Nothnagel M, Szafranski K, Huse K, Schumann F, Schreiber S, Platzer M, Krawczak M, Hampe J, Brosch M

Genome Res. 2012, 22, 2208-2218 [PubMed]


UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages

Greinert R, Volkmer B, Henning S, Breitbart EW, Greulich KO, Cardoso MC, Rapp A

Nucleic Acids Res. 2012, 40, 10263-10273 [PubMed]


Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment

Morgado I, Wieligmann K, Bereza M, Rönicke R, Meinhardt K, Annamalai K, Baumann M, Wacker J, Hortschansky P, Malesevic M, Parthier C, Mawrin C, Schiene-Fischer C, Reymann KG, Stubbs MT, Balbach J, Görlach M, Horn U, Fändrich M

Proc Natl Acad Sci USA. 2012, 109, 12503-12508 [PubMed]


DNA damage checkpoints in stem cells, ageing and cancer

Sperka T, Wang J, Rudolph KL

Nat Rev Mol Cell Biol. 2012, 13, 579-590 [PubMed]


Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo

Bui M, Dimitriadis EK, Hoischen C, An E, Quénet D, Giebe S, Nita-Lazar A, Diekmann S, Dalal Y

Cell. 2012, 150, 317-326 [PubMed]


Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

Hamidi T, Algül H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, Urrutia R, Schmid RM, Iovanna JL

J Clin Invest. 2012, 122, 2092-2103 [PubMed]


The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif

Ohlenschläger O, Kuhnert A, Schneider A, Haumann S, Bellstedt P, Keller H, Saluz HP, Hortschansky P, Hänel F, Grosse F, Görlach M, Pospiech H

Nucleic Acids Res. 2012, 40, 8309-8324 [PubMed]


Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium

Chang GS, Noegel AA, Mavrich TN, Müller R, Tomsho L, Ward E, Felder M, Jiang C, Eichinger L, Glöckner G, Schuster SC, Pugh BF

Genome Res. 2012, 22, 1098-1106 [PubMed]


Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia

Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M

FASEB J. 2012, 26, 2424-2436 [PubMed]


Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis

Begus-Nahrmann Y, Hartmann D, Kraus J, Eshraghi P, Scheffold A, Grieb M, Rasche V, Schirmacher P, Lee HW, Kestler HA, Lechel A, Rudolph KL

J Clin Invest. 2012, 122, 2283-2288 [PubMed]


Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function

Song Z, Zhang J, Ju Z, Rudolph KL

Aging Cell. 2012, 11, 449-455 [PubMed]


Telomere dysfunction puts the brakes on oncogene-induced cancers

Günes C, Rudolph KL

EMBO J. 2012, 31, 2833-2834 [PubMed]


Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

Vandevyver S, Dejager L, Van Bogaert T, Kleyman A, Liu Y, Tuckermann J, Libert C

J Clin Invest. 2012, 122, 2130-2140 [PubMed]


Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation

Katz SF, Lechel A, Obenauf AC, Begus-Nahrmann Y, Kraus JM, Hoffmann EM, Duda J, Eshraghi P, Hartmann D, Liss B, Schirmacher P, Kestler HA, Speicher MR, Rudolph KL

Gastroenterology. 2012, 142, 1229-1239 [PubMed]


Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

Zarse K, Schmeisser S, Groth M, Priebe S, Beuster G, Kuhlow D, Guthke R, Platzer M, Kahn CR, Ristow M

Cell Metab. 2012, 15, 451-465 [PubMed]


Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex

Kleger A, Mahaddalkar PU, Katz SF, Lechel A, Joo JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus JM, Cantz T, Kestler HA, Zaehres H, Schöler H, Rudolph KL

Gastroenterology. 2012, 142, 907-917 [PubMed]


Fungal-induced cell cycle impairment, chromosome instability and apoptosis via differential activation of NF-κB

Ben-Abdallah M, Sturny-Leclère A, Avé P, Louise A, Moyrand F, Weih F, Janbon G, Mémet S

PLoS Pathog. 2012, 8, e1002555 [PubMed]


Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV1.4

Tietze AA, Tietze D, Ohlenschläger O, Leipold E, Ullrich F, Kühl T, Mischo A, Buntkowsky G, Görlach M, Heinemann SH, Imhof D

Angew Chem Int Ed Engl. 2012, 51, 4058-4061 [PubMed]


A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL

Cell. 2012, 148, 1001-1014 [PubMed]


Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting.

Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Evans DG, Giancotti F, Hanemann CO, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N.

Acta Neuropathol. 2012, 123, 369-380 [PubMed]


Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease

Watabe-Rudolph M, Song Z, Lausser L, Schnack C, Begus-Nahrmann Y, Scheithauer MO, Rettinger G, Otto M, Tumani H, Thal DR, Attems J, Jellinger KA, Kestler HA, von Arnim CA, Rudolph KL

Neurology. 2012, 78, 569-577 [PubMed]


Disrupted-in-schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons

Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J

J Neurosci 2012, 32, 738-745 [PubMed]


Structural basis of β-amyloid-dependent synaptic dysfunctions

Haupt C, Leppert J, Rönicke R, Meinhardt J, Yadav JK, Ramachandran R, Ohlenschläger O, Reymann KG, Görlach M, Fändrich M.

Angew Chem Int Ed Engl. 2012, 51, 1576-1579 [PubMed]


A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons

Li R, Yang YG, Gao Y, Wang ZQ, Tong WM

Cell Res. 2012, 22, 859-872 [PubMed]


Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri – a new vertebrate model for age research

Kirschner J, Weber D, Neuschl C, Franke A, Böttger M, Zielke L, Powalsky E, Groth M, Shagin D, Petzold A, Hartmann N, Englert C, Brockmann GA, Platzer M, Cellerino A, Reichwald K

Aging Cell 2012, 11, 252-261 [PubMed]


Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging

Tozzini ET, Baumgart M, Battistoni G, Cellerino A

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Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity

Creemers J, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, Meulemans S, Than ME, Yengo L, Tauber M, Balkau B, Elliott P, Jarvelin M-R, Van Hul W, Van Gaal L, Hoberl F, Pattoul F, Froguel P, Meyre D

Diabetes 2012, 61, 383-390 [PubMed]


Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X

Groh J, Weis J, Zieger H, Stanley E, Heuer H, Martini R

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Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

Kleiman A, Hübner S, Rodriguez Parkitna JM, Neumann A, Hofer S, Weigand MA, Bauer M, Schmid W, Schütz G, Libert C, Reichardt HM, Tuckermann JP

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Koeberle SC, Romir J, Fischer S, Koeberle A, Schattel V, Albrecht W, Grütter C, Werz O, Rauh D, Stehle T, Laufer SA

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Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells

Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP

Proc Natl Acad Sci USA. 2011, 108, 19317-19322 [PubMed]

Evaluated by "Faculty of 1000"

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1Cdc25 pathway

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Nat Cell Biol. 2011, 13, 1325-1334 [PubMed]


Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor

Rose AJ, Díaz MB, Reimann A, Klement J, Walcher T, Krones-Herzig A, Strobel O, Werner J, Peters A, Kleyman A, Tuckermann JP, Vegiopoulos A, Herzig S

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Requirement for DNA ligase IV during embryonic neuronal development

Gatz SA, Ju L, Gruber R, Hoffmann E, Carr AM, Wang ZQ, Liu C, Jeggo PA

J Neurosci. 2011, 31, 10088-10100 [PubMed]


Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication

Heidel AJ, Lawal HM, Felder M, Schilde C, Helps NR, Tunggal B, Rivero F, John U, Schleicher M, Eichinger L, Platzer M, Noegel AA, Schaap P, Glöckner G

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Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state

Prendergast L, van Vuuren C, Kaczmarczyk A, Doering V, Hellwig D, Quinn N, Hoischen C, Diekmann S, Sullivan KF

PLoS Biol. 2011, 9, e1001077 [PubMed]


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Hartmann N, Reichwald K, Wittig I, Dröse S, Schmeisser S, Lück C, Hahn C, Graf M, Gausmann U, Terzibasi E, Cellerino A, Ristow M, Brandt U, Platzer M, Englert C

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Powolny-Budnicka I, Riemann M, Tänzer S, Schmid RM, Hehlgans T, Weih F

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Host plant shifts affect a major defense enzyme in Chrysomela lapponica

Kirsch R, Vogel H, Muck A, Reichwald K, Pasteels JM, Boland W

Proc Natl Acad Sci USA 2011, 108, 4897-4901 [PubMed]


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Wu M, Zampini M, Bussiek M, Hoischen C, Diekmann S, Hayes F

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Revealing the position of the substrate in nickel superoxide dismutase: a model study

Tietze D, Voigt S, Mollenhauer D, Tischler M, Imhof D, Gutmann T, González L, Ohlenschläger O, Breitzke H, Görlach M, Buntkowsky G

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Lee MK, Tong WM, Wang ZQ, Sabapathy K

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Identification of adult nephron progenitors capable of kidney regeneration in zebrafish

Diep CQ, Ma D, Deo RC, Holm TM, Naylor RW, Arora N, Wingert RA, Bollig F, Djordjevic G, Lichman B, Zhu H, Ikenaga T, Ono F, Englert C, Cowan CA, Hukriede NA, Handin RI, Davidson AJ

Nature 2011, 470, 95-100 [PubMed]


Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi

Burmester A*, Shelest E*, Glöckner G*, Heddergott C*, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA

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An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

Rauch A*, Gossye V*, Bracke D, Gevaert E, Jacques P, Van Beneden K, Vandooren B, Rauner M, Hofbauer LC, Haegeman G, Elewaut D, Tuckermann JP**, De Bosscher K**

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Nowack EC, Vogel H, Groth M, Grossman AR, Melkonian M, Glöckner G

Mol Biol Evol. 2011, 28, 407-422 [PubMed]


Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled {alpha}-subunits

Valkova C*, Albrizio M*, Röder IV, Schwake M, Betto R, Rudolf R**, Kaether C**

Proc Natl Acad Sci USA 2011, 108, 621-625 (*,**equal contribution) [PubMed]


Unlocking the barley genome by chromosomal and comparative genomics

Mayer KF, Martis M, Hedley PE, Simková H, Liu H, Morris JA, Steuernagel B, Taudien S, Roessner S, Gundlach H, Kubaláková M, Suchánková P, Murat F, Felder M, Nussbaumer T, Graner A, Salse J, Endo T, Sakai H, Tanaka T, Itoh T, Sato K, Platzer M, Matsumoto T, Scholz U, Dolezel J, Waugh R, Stein N.

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Wicker T, Mayer KF, Gundlach H, Martis M, Steuernagel B, Scholz U, Simková H, Kubaláková M, Choulet F, Taudien S, Platzer M, Feuillet C, Fahima T, Budak H, Dolezel J, Keller B, Stein N

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Proc Natl Acad Sci USA. 2010, 107, 20317-20322 [PubMed]


Proteomic and functional analysis of the mitotic Drosophila centrosome

Müller H, Schmidt D, Steinbrink S, Mirgorodskaya E, Lehmann V, Habermann K, Dreher F, Gustavsson N, Kessler T, Lehrach H, Herwig R, Gobom J, Ploubidou A, Boutros M, Lange BMH

EMBO J 2010, 29, 3344-3357 [PubMed]


Thymus-derived glucocorticoids mediate androgen effects on thymocyte homeostasis

Chen Y, Qiao S, Tuckermann J, Okret S, Jondal M

FASEB J 2010, 24, 5043-5051 [PubMed]


WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase

Chakraborty P, Grosse F

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Schulz A, Geissler KJ, Kumar S, Leichsenring G, Morrison H*, Baader SL*

J Neurosci 2010, 30, 10177-10186 (*equal contribution) [PubMed]


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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C

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EMBO review

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor

Rauch A, Seitz S, Baschant, U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss M, Angel PE, Lerner UH, David JP, Reichard HM, Amling M, Schütz G, Tuckermann J

Cell Metab 2010, 11, 517-531 [PubMed]


Processing of the NF-κB2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation

Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E

J Bone Miner Res 2010, 25, 1058-1067 [PubMed]


Cross talk between stimulated NF-κB and the tumor suppressor p53

Schneider G, Henrich A, Greiner G, Wolf V, Lovas A, Wieczorek M, Wagner T, Reichardt S, von Werder A, Schmid RM, Weih F, Heinzel T, Saur D, Krämer OH

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The pivotal role of the alternative NF-κB pathway in maintenance of basal bone homeostasis and osteoclastogenesis

Soysa NS, Alles N, Weih D, Lovas A, Mian AH, Shimokawa H, Yasuda H, Weih F, Jimi E, Ohya K, Aoki K

J Bone Miner Res. 2010, 25, 809-818 [PubMed]

Selected as "exceptional" by "Faculty of 1000"

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME

Proc Natl Acad Sci USA. 2010, 107, 5381-5386 [PubMed]


Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns

Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJB, Englert C, Petry M, Mommersteeg MTM, Christoffels VM, Niederreither K, Kispert A

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Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells upon combined TNFR1/LTβR NF-κB signaling

Lötzer K, Döpping S, Connert S, Gräbner R, Spanbroek R, Lemser B, Beer M, Hildner M, Hehlgans T, van der Wall M, Mebius RE, Lovas A, Randolph GJ, Weih F*, Habenicht AJR*

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Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K , Nyabi O, Haigh K , Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David J-P, Behrens A, Nagy A, Carmeliet G, Haigh JJ

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Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity

Friedrich RP, Tepper K, Rönicke R, Soom M, Westermann M, Reymann K, Kaether C, Fändrich M

Proc Natl Acad Sci USA. 2010, 107, 1942-1947 [PubMed]


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C/EBPβΔuORFmice - a genetic model for uORF-mediated translational control in mammals

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Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling

Lindner I, Hemdan NY, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, Hollborn M, Thal D, Gebhardt R, Birkenmeier G

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Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy

Kurth I, Pamminger T, Hennings JC, Soehendra D, Huebner AK, Rotthier A, Baets J, Senderek J, Topaloglu H, Farrell SA, Nürnberg G, Nürnberg P, De Jonghe P, Gal A, Kaether C, Timmerman V, Hübner CA

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X-chromosomal variation is associated with slow progression to AIDS in HIV-infected women

Siddiqui RA, Sauermann U, Altmüller J, Fritzer E, Nothnagel M, Dalibor N, Fellay J, Kaup FJ, Stahl-Hennig C, Nürnberg P, Krawczak M, Platzer M

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A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros

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In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice

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Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

Fisch KM, Gurgui C, Heycke N, van der Sar SA, Anderson SA, Webb VL, Taudien S, Platzer M, Rubio BK, Robinson SJ, Crews P, Piel J

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Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

Skouloudaki K, Puetz M, Simons M, Courbard JR, Boehlke C, Hartleben B, Engel C, Moeller MJ, Englert C, Bollig F, Schäfer T, Ramachandran H, Mlodzik M, Huber TB, Kuehn EW, Kim E, Kramer-Zucker A, Walz G

Proc Natl Acad Sci USA 2009, 106, 8579-8584 [PubMed]


The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation

Moniot B, Declosmenil F, Barrionuevo F, Scherer G, Aritake K, Malki S, Marzi L, Cohen-Solal A, Georg I, Klattig J, Englert C, Kim Y, Capel B, Eguchi N, Urade Y, Boizet-Bonhoure B, Poulat F

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Systematic evaluation of the effect of common SNPs on pre-mRNA splicing

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Effects of dietary restriction on mortality and age-related phenotypes in the short-lived fish Nothobranchius furzeri

Terzibasi E, Lefrançois C, Domenici P, Hartmann N, Graf M, Cellerino A

Aging Cell 2009, 8, 88-99 [PubMed]


DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution

Zhang Y, Rohde C, Tierling S, Jurkowski TP, Bock C, Santacruz D, Ragozin S, Reinhardt R, Groth M, Walter J, Jeltsch A

PLoS Genet 2009, 5, e1000438 [PubMed]


High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research

Reichwald K, Lauber C, Nanda I, Kirschner J, Hartmann N, Schories S, Gausmann U, Taudien S, Schilhabel MB, Szafranski K, Glöckner G, Schmid M, Cellerino A, Schartl M, Englert C, Platzer M

Genome Biol 2009, 10, R16 [PubMed]


Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice

Gräbner R, Lötzer K, Döpping S, Hildner M, Radke D, Beer M, Spanbroek R, Lippert B, Reardon CA, Getz GS, Fu Y-X, Hehlgans T, Mebius RE, van der Wall M, Kruspe D, Englert C, Lovas A, Hu D, Randolph GJ, Weih F, Habenicht AJR

J Exp Med 2009, 206, 233-248 [PubMed]


Selected as "exceptional" by "Faculty of 1000"

A phosphorylation-acetylation switch regulates STAT1 signaling

Krämer OH, Knauer SK, Greiner G, Jandt E, Reichardt S, Gührs KH, Stauber RH, Böhmer FD, Heinzel T

Genes Dev 2009, 23, 223-235 [PubMed]


Critical role of macrophages in glucocorticoid driven vascular calcification in a mouse-model of atherosclerosis

Preusch MR, Rattazzi M, Albrecht C, Merle U, Tuckermann J, Schütz G, Blessing E, Zoppellaro G, Pauletto P, Krempien R, Rosenfeld ME, Katus HA, Bea F

Arterioscler Thromb Vasc Biol 2008, 28, 2158-2164 [PubMed]


The wave property of heavy molecules - Its use in mass spectrometry

Greulich KO

Angew Chem Int Ed Engl 2008, 47, 7990-7991 [PubMed]


The structure of the 5'-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation

Karagyozov L, Godfrey R, Böhmer SA, Petermann A, Hölters S, Ostman A, Böhmer FD

Nucleic Acids Res. 2008, 36, 4443-4453 [PubMed]


Lack of NF-κB2/p100 causes a RelB-dependent block in early B lymphopoiesis

Guo F, Tänzer S, Busslinger M, Weih F

Blood 2008, 112, 551-559 [PubMed]


Paired {beta}-sheet structure of an A{beta}(1-40) amyloid fibril revealed by electron microscopy

Sachse C, Fändrich M, Grigorieff N

Proc Natl Acad Sci U S A 2008, 105, 7462-7466 [PubMed]


SNP and haplotype mapping for genetic analysis in the rat

STAR Consortium, Saar K, Beck A, Bihoreau MT, Birney E, Brocklebank D, Chen Y, Cuppen E, Demonchy S, Dopazo J, Flicek P, Foglio M, Fujiyama A, Gut IG, Gauguier D, Guigo R, Guryev V, Heinig M, Hummel O, Jahn N, Klages S, Kren V, Kube M, Kuhl H, Kuramoto T, Kuroki Y, Lechner D, Lee YA, Lopez-Bigas N, Lathrop GM, Mashimo T, Medina I, Mott R, Patone G, Perrier-Cornet JA, Platzer M, Pravenec M, Reinhardt R, Sakaki Y, Schilhabel M, Schulz H, Serikawa T, Shikhagaie M, Tatsumoto S, Taudien S, Toyoda A, Voigt B, Zelenika D, Zimdahl H, Hubner N

Nat Genet 2008, 40, 560-566 [PubMed]


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Hiller M, Platzer M

Trends Genet 2008, 24, 246-255 [PubMed]


Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling

Buch S, Melcher C, Bauer M, Katzenberger J, Pankratz MJ

Cell Metab 2008, 7, 321-332 [PubMed]


Chromatophore genome sequence of paulinella sheds light on acquisition of photosynthesis by eukaryotes

Nowack EC, Melkonian M, Glöckner G

Curr Biol 2008, 18, 410-418 [PubMed]


Dynamics of inner kinetochore assembly and maintenance in living cells

Hemmerich P, Weidtkamp-Peters S, Hoischen C, Schmiedeberg L, Erliandri I, Diekmann S

J Cell Biol 2008, 180, 1101-1114 [PubMed]


Centromere anatomy in the multidrug-resistant pathogen Enterococcus faecium

Derome A, Hoischen C, Bussiek M, Grady R, Adamczyk M, Keedzierska B, Diekmann S, Barillà D, Hayes F

Proc Natl Acad Sci U S A 2008, 105, 2151-2156 [PubMed]


Supreme enLIGHTenment: damage recognition and signaling in the mammalian UV response

Herrlich P, Karin M, Weiss C

Mol Cell 2008, 29, 279-290 [PubMed]


Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

Nguyen T, Ishida K, Jenke-Kodama H, Dittmann E, Gurgui C, Hochmuth T, Taudien S, Platzer M, Hertweck C, Piel J

Nat Biotechnol 2008, 26, 225-233 [PubMed]


Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock

Pulivarthy SR, Tanaka N, Welsh DK, De Haro L, Verma IM, Panda S

Proc Natl Acad Sci U S A 2007, 104, 20356-20361 [PubMed]


Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

Habicht G, Haupt C, Friedrich RP, Hortschansky P, Sachse C, Meinhardt J, Wieligmann K, Gellermann GP, Brodhun M, Götz J, Halbhuber K-J, Röcken C, Horn U, Fändrich M

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Endogenous transforming growth factor beta1 suppresses inflammation and promotes survival in adult CNS

Makwana M, Jones LL, Cuthill D, Heuer H, Bohatschek M, Hristova M, Friedrichsen S, Ormsby I, Bueringer D, Koppius A, Bauer K, Doetschman T, Raivich G

J Neurosci 2007, 27, 11201-11213 [PubMed]


The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish

Ferg M, Sanges R, Gehrig J, Kiss J, Bauer M, Lovas A, Szabo M, Yang L, Straehle U, Pankratz MJ, Olasz F, Stupka E, Müller F

EMBO J 2007, 26, 3945-3956 [PubMed]


Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns

Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M

Genome Biol 2007, 8, R154 [PubMed]


Constitutive alternative NF-κB signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen

Guo F, Weih D, Meier E, Weih F

Blood 2007, 110, 2381-2389 [PubMed]


Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1

Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H, Haass C

EMBO Rep 2007, 8, 743-748 [PubMed]

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Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy

Tuckermann JP, Kleiman A, Moriggl R, Spanbroek R, Neumann A, Illing A, Clausen BE, Stride B, Förster I, Habenicht AJ, Reichardt HM, Tronche F, Schmid W, Schütz G

J Clin Invest 2007, 117, 1381-1390 [PubMed]

Comment in Cell 129, May 18, 2007 (Immunology Select)


Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism

Partida-Martinez LP, Monajembashi S, Greulich KO, Hertweck C

Curr Biol 2007, 17, 773-777 [PubMed]


Skin inflammation in RelB-/- mice leads to defective immunity and impaired clearance of vaccinia virus

Freyschmidt EJ, Mathias CB, MacArthur DH, Laouar A, Narasimhaswamy M, Weih F, Oettgen HC

J Allergy Clin Immunol 2007, 119, 671-679 [PubMed]


Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8

Trajkovic M, Visser TJ, Mittag J, Horn S, Lukas J, Darras VM, Raivich G, Bauer K, Heuer H

J Clin Invest 2007, 117, 627-635 [PubMed]

see also: Editorial in Nature Clinical Practice (July 2007)


Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of ras and rac

Morrison H, Sperka T, Manent J, Giovannini M, Ponta H, Herrlich P

Cancer Res 2007, 67, 520-527 [PubMed]


A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Günther S, Prescott NJ, Onnie CM, Häsler R, Sipos B, Fölsch UR, Lengauer T, Platzer M, Mathew CG

Nat Genet 2007, 39, 2007-2011 [PubMed]


Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks

Yang YG, Saidi A, Frappart PO, Min W, Barrucand C, Dumon-Jones V, Michelon J, Herceg Z, Wang ZQ

EMBO J 2006, 25, 5527-5538 [PubMed]


SNPSplicer: systematic analysis of SNP-dependent splicing in genotyped cDNAs

ElSharawy A, Manaster C, Teuber M, Rosenstiel P, Kwiatkowski R, Huse K, Platzer M, Becker A, Nürnberg P, Schreiber S, Hampe J

Hum Mutat 2006, 27, 1129-1134 [PubMed]


Sequencing errors or SNPs at splice-acceptor guanines in dbSNP?

Platzer M, Hiller M, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, Huse K

Nat Biotechnol 2006, 24, 1068-1070 [PubMed]


Constraints on the structure of (CUG)97-RNA from MAS solid state NMR spectroscopy

Riedel K, Herbst C, Häfner S, Leppert J, Ohlenschläger O, Swanson MS, Görlach M, Ramachandran R

Angew Chem Int Ed Engl 2006, 45, 5620-5623 [PubMed]


Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

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A translational control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell

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