Publications 2000

 

  • Anders R, Ohlenschläger O, Soskic V, Wenschuh H, Heise B, Brown LR. The NMR solution structure of the ion channel peptaibol chrysospermin C bound to dodecylphosphocholine micelles. Eur J Biochem 2000, 267, 1784-1794. [PubMed]
  • Augsten K, Mühlig P, Herrmann C. Glycoproteins and skin-core structure in Nephila clavipes spider silk observed by light and electron microscopy. Scanning 2000, 22, 12-15. [PubMed]
  • Bechert T, Steinrücke P, Guggenbichler JP. A new method for screening anti-infective biomaterials. Nat Med 2000, 6, 1053-1056. [PubMed]
  • Böhm KJ, Stracke R, Baum M, Zieren M, Unger E. Effect of temperature on kinesin-driven microtubule gliding and kinesin ATPase activity. FEBS Lett 2000, 466, 59-62. [PubMed]
  • Böhm KJ, Stracke R, Unger E. Speeding up kinesin-driven microtubule gliding in vitro by variation of cofactor composition and physicochemical parameters. Cell Biol Int 2000, 24, 335-341. [PubMed]
  • Borcherding H, Leikefeld S, Frey C, Diekmann S, Steinrücke P. Enzymatic microtiter plate-based nitrate detection in environmental and medical analysis. Anal Biochem 2000, 282, 1-9. [PubMed]
  • Brandl M, Meyer M, Sühnel J. Water-mediated base pairs in RNA - A quantum-chemical study. J Phys Chem A 2000, 104, 11177-11187.
  • Burckhardt G, Förtsch I, Simon H, Birch-Hirschfeld E, Kittler L, Schütz H, Sharma S, Lown W, Zimmer C. DNA sequence recognition of cross-linked polyamid: CD studies, footprinting and effects on the activity of DNA gyrase. J Biomol Struct Dyn. 2000, 11, 355-363.
  • Chandler D, Angelicheva D, Heather L, Gooding R, Gresham D, Yanakiev P, de Jonge R, Baas F, Dye D, Karagyozov L, Savov A, Blechschmidt K, Keats B, Thomas PK, King RH, Starr A, Nikolova A, Colomer J, Ishpekova B, Tournev I, Urtizberea JA, Merlini L, Butinar D, Chabrol B, Voit T, Baethmann M, Nedkova V, Corches A, Kalaydjieva L. Hereditary motor and sensory neuropathy - Lom (HMSNL): refined genetic mapping in Romani (Gypsy) families from several European countries. Neuromuscul Disord 2000, 10, 584-591. [PubMed]
  • Chen M, Dahlmann B, Hemmerich P, Rockel D, von Mikecz A. Proteasome-dependent processing of nuclear autoantigens. Autoimmunity, Autoantigens, Autoantibodies 2000, 1, 242-248.


  • Diekmann S. Reviews in molecular biotechnology: an introductory editorial. Rev Mol Biotechnol 2000, 74, 1.
  • Esa A, Edelmann P, Kreth G, Trakhtenbrot L, Amariglio N, Rechavi G, Hausmann M, Cremer C. Three-dimensional spectral precision distance microscopy of chromatin nano-structures after triple-colour DNA labelling: a study of the BCR region on chromosome 22 and the Philadelphia chromosome. J Microsc 2000, 199, 96-105. [PubMed]
  • Ghadimi BM, Sackett DL, Difilippantonio MJ, Schröck E, Neumann T, Jauho A, Auer G, Ried T. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer 2000, 27, 183-190. [PubMed]
  • Glienke J, Schmitt AO, Pilarsky C, Hinzmann B, Weiss B, Rosenthal A, Thierauch KH. Differential gene expression by endothelial cells in distinct angiogenic states. Eur J Biochem 2000, 267, 2820-2830. [PubMed]
  • Glöckner G. Large scale sequencing and analysis of AT rich eukaryote genomes. Curr Genomics 2000, 1, 289-299.
  • Glöckner G, Rosenthal A, Valentin K. The structure and gene repertoire of an ancient red algal plastid genome. J Mol Evol 2000, 51, 382-390. [PubMed]
  • Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D. Sequence, structure and evolution of a complete human olfactory receptor gene cluster. Genomics 2000, 63, 227-245. [PubMed]
  • Gothe G, Böhm KJ, Unger E. A new species of the genus Rhizoplasma Verworn (1896). Acta Protozool 2000, 39, 165-167.
  • Greulich KO. Single fullerene molecules and the wave-particle dualism. Angew Chem Int Ed Engl 2000, 39, 4242-4244.
  • Greulich KO, Pilarczyk G, Hoffmann A, Meyer Zu Hörste G, Schäfer B, Uhl V, Monajembashi S. Micromanipulation by laser microbeam and optical tweezers: from plant cells to single molecules. J Microsc 2000, 198, 182-187. [PubMed]


  • Grunau C, Hindermann W, Rosenthal A. Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes. Hum Mol Genet 2000, 9, 2651-2663. [PubMed]
  • Grunau C, Schattevoy R, Mache N, Rosenthal A. MethTools - a toolbox to visualize and analyze DNA mehtylation data. Nucleic Acids Res 2000, 28, 1053-1058. [PubMed]
  • Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML; Chromosome 21 mapping and sequencing consortium. The DNA sequence of human chromosome 21. Nature 2000, 405, 311-319. [PubMed]
  • Heise B, Leppert J, Ramachandran R. Characterization of 15N chemical shift tensors via 15N-13C REDOR and 15N-1H dipolar-shift CPMAS NMR spectroscopy. Solid State Nucl Magn Reson 2000, 16, 177-187. [PubMed]
  • Heise B, Leppert J, Ramachandran R. REDOR with adiabatic dephasing pulses. J Magn Reson 2000, 146, 181-187. [PubMed]
  • Held N, Hausmann M, Perner B, Greulich KO. Optische Rasternahfeldmikroskopie in der Zytogenetik. Chemie in Labor und Biotechnik 2000, 51, 324-327.
  • Hemmerich P, von Mikecz A. Antinuclear autoantibodies: fluorescent highlights on structure and function in the nucleus. Int Arch Allergy Immunol 2000, 123, 16-27. [PubMed]
  • Hemmerich P, Stoyan T, Wieland G, Koch M, Lechner J, Diekmann S. Interaction of yeast kinetochore proteins with centromere-protein/transcription factor Cbf1. Proc Natl Acad Sci U S A 2000, 97, 12583-12588. [PubMed]
  • Hoffmann A, Meyer zu Hörste G, Pilarczyk G, Monaembashi S, Uhl V, Greulich KO. Optical tweezers for confocal microscopy. Appl Phys 2000, B71, 747-753.
  • Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am J Hum Genet 2000, 67, 47-58. [PubMed]


  • Kießlich A, von Mikecz A, Hemmerich P. The role of nuclear bodies in transcription. Autoantigens, Autoantibodies, Autoimmunity 2000, 1, 110-120.
  • Kirschstein O, Sip M, Kittler L. Quantitative and sequence-specific analysis of DNA-ligand interaction by means of fluorescent intercalator probes. J Mol Recognit 2000, 13, 157-163. [PubMed]
  • Kittler L, Wollweber L. Down-regulation of H tau 40 protein expression by minor groove binders. Nucleosides Nucleotides Nucleic Acids 2000, 19, 1241-1248. [PubMed]
  • Kolpashchikov DM, Ivanova TM, Boghachev VS, Nasheuer HP, Weisshart K, Favre A, Pestryakov PE, Lavrik OI. Synthesis of base-substituted dUTP analogs carrying photoreactive 2-Nitro-5-azidobenzoyl group attached to 5'-position of uridine and its application to study human replication protein A by photoaffinity labeling. Bioconjug Chem 2000, 11, 445-451. [PubMed]
  • Leppert J, Heise B, Ramachandran R. 15N chemical shift tensor magnitude and orientation in the molecular frame of uracil determined via MAS NMR. J Magn Reson 2000, 145, 307-314. [PubMed]
  • Leppert J, Heise B, Ramachandran R. Redor in IS1S2 systems. J Biomol NMR 2000, 18, 153-164. [PubMed]
  • Liu M, Gothe G, Berg H. Electroporation and fusion of human cancer cells modified by amino acids and polypeptides. Electro- and Magnetobiology 2000, 19, 331-338.
  • Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. Genome Res 2000, 10, 758-775.
  • von Mikecz A, Zhang S, Montminy M, Tan EM, Hemmerich P. CREB-binding protein CBP/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus. J Cell Biol 2000, 150, 265-273. [PubMed]


  • Momeni P, Glöckner G, Schmidt O, von Holtum D, Albrecht B, Gillessen-Kaesbach G, Hennekam R, Meinecke P, Zabel B, Rosenthal A, Horsthemke B, Lüdecke HJ. Mutations in a new gene, encoding a zinc-finger protein, cause tricho- rhino-phalangeal syndrome type I. Nat Genet 2000, 24, 71-74. [PubMed]
  • Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, Görlach M, van Heel M, Brimacombe R. The 3D arrangement of the 23S and 5S rRNA in the Escherichia coli 50S ribosomal subunit at 7.5 Å resolution. J Mol Biol 2000, 298, 35-59. [PubMed]
  • Novikova SI, Bushueva AM, Trachuk LA, Konstantinova GE, Serkina AV, Hoischen C, Gumpert J, Chestukhina GG, Mankin A, Shevelev AB. Introduction of a mini-gene encoding a five-amino acid peptide confers erythromycin resistance on Bacillus subtilis and provides temporary erythromycin protection in Proteus mirabilis. FEMS Microbiol Lett 2000, 182, 213-218. [PubMed]
  • Opitz A, Roemer E, Haas W, Görls H, Werner W, Gräfe U. Regioselective synthesis of benzo[g]isoquinoline-5,10-dione derivatives as DNA intercalators. Tetrahedron 2000, 56, 5147-5155.
  • Orti R, Rachidi M, Vialard F, Toyama K, Lopes C, Taudien S, Rosenthal A, Yaspo ML, Sinet PM, Delabar JM. Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5. Genomics 2000, 64, 203-210. [PubMed]
  • Pineda LF, Liebmann C, Hensellek S, Paegelow I, Steinmetzer T, Schweinitz A, Stürzebecher J, Reissmann S. Novel non-peptide lead structures for bradykinin B2-receptor antagonists. Lett Peptide Sci 2000, 7, 69-77.
  • Rapp A, Bock C, Dittmar H, Greulich KO. UV-A breakage sensitiviy of human chromosomes measured by COMET-FISH depends on gene densiy and not on the chromosome size. J Photochem Photobiol B 2000, 56, 109-117. [PubMed]
  • Rauch J, Wolf D, Craig JM, Hausmann M, Cremer C. Quantitative microscopy after fluorescence in situ hybridization - a comparison between repeat-depleted and non-depleted DNA probes. J Biochem Biophys Methods 2000, 44, 59-72. [PubMed]
  • Rauch J, Wolf D, Hausmann M, Cremer C. The influence of formamide on thermal denaturation profiles of DNA and metaphase chromosomes in suspensions. Z Naturforsch [C] 2000, 55, 737-746. [PubMed]
  • Reichert J, Jabs A, Slickers P, Sühnel J. The IMB Jena Image Library of biological macromolecules. Nucleic Acids Res 2000, 28, 246-249. [PubMed]


  • Reichwald K, Thiesen J, Wiehe T, Weitzel J, Poustka WA, Rosenthal A, Platzer M, Strätling WH, Kioschis P. Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. Mamm Genome 2000, 11, 182-190. [PubMed]
  • Russwurm S, Böhm KJ, Mühlig P, Wiederhold M, König K, Reinhart K. Lipopolysaccharide induces distinct alterations in the microtubule cytoskeleton of monocytes. Cell Biol. Toxicol 2000, 16, 339-346. [PubMed]
  • Schäfer B, Gemeinhardt H, Uhl V, Greulich KO. Single molecule DNA restriction analysis in the light microscope. Single Mol 2000, 1, 33-40.
  • Schell U, Grün M, Hilgenfeld R. Binding of insulin to its receptor: towards an understanding in three dimensions. Chembiochem 2000, 1, 37-40. [PubMed]
  • Schneider C, Sühnel J. A molecular dynamics simulation study of coaxial stacking in RNA. J Biomol Struct Dyn 2000, 18, 345-352. [PubMed]
  • Schröck E, Padilla-Nash H. Spectral karyotyping and multicolor fluorescence in situ hybridization reveal new tumor-specific chromosomal aberrations. Semin Hematol 2000, 37, 334-347. [PubMed]
  • Simon H, Kittler L, Baird E, Dervan P, Zimmer C. Selective inhibition of DNA gyrase in vitro by a GC specific eight-ring hairpin polyamide at nanomolar concentration. FEBS Lett 2000, 471, 173-176. [PubMed]
  • Slavov D, Hattori M, Sakaki Y, Rosenthal A, Shimizu N, Minoshima S, Kudoh J, Yaspo ML, Ramser J, Reinhardt R, Reimer C, Clancy K, Rynditch A, Gardiner K. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. Gene 2000, 247, 215-232. [PubMed]
  • Steinmetzer T, Batdordshjin M, Pineda F, Seyfarth L, Vogel A, Reissmann S, Hauptmann J, Stürzebecher J. New bivalent thrombin inhibitors with N(alpha)(methyl)arginine at the P1-position. Biol Chem 2000, 381, 603-610. [PubMed]
  • Steinmetzer K, Hillisch A, Behlke J, Brantl S. Transcriptional repressor CopR: amino acids involved in forming the dimeric interface. Proteins 2000, 39, 408-416. [PubMed]


  • Steinrücke P, Aldinger U, Hill O, Hillisch A, Basch R, Diekmann S. Design of helical proteins for realtime endoproteinase assays. Anal Biochem 2000, 286, 26-34. [PubMed]
  • Stracke R, Böhm KJ, Burgold J, Schacht HJ, Unger E. Physical and technical parameters determining the functioning of a kinesin-based cell-free motor system. Nanotechnology 2000, 11, 52-56.
  • Stühmeier F, Hillisch A, Clegg RM, Diekman S. Fluorescence energy transfer analysis of DNA structures containing several bulges and their interaction with CAP. J Mol Biol 2000, 302, 1081-1100. [PubMed]
  • Taudien S, Rump A, Platzer M, Drescher B, Schattevoy R, Gloeckner G, Dette M, Baumgart C, Weber J, Menzel U, Rosenthal A. RUMMAGE - a high throughput sequence annotation system. Trends Genet 2000, 16, 519-520. [PubMed]
  • Tunnicliffe RG, Gloeckner G, Elgar GS, Brenner S, Rosenthal A. Comparative analysis of the PCOLCE region in Fugu rubripes using a new automated annotation tool. Mamm Genome 2000, 11, 213-219. [PubMed]
  • Weiss MS, Palm GJ, Hilgenfeld R. Crystallization, structure solution and refinement of hen egg-white lysozyme at pH 8.0 in the presence of MPD. Acta Crystallogr D Biol Crystallogr 2000, 56, 952-958. [PubMed]
  • Weisshart K, Förster H, Kremmer E, Schlott B, Grosse F, Nasheuer HP. Protein-protein interactions of the primase subunits p58 and p48 with simian virus 40 T antigen are required for efficient primer synthesis in a cell-free system. J Biol Chem 2000, 275, 17328-17337. [PubMed]
  • Wiehe T, Mountain J, Parham P, Slatkin M. Distinguishing recombination and intragenic gene conversion by linkage disequilibrium patters. Genet Res 2000, 75, 61-73. [PubMed]
  • Wölfl S, Diekmann S. Aptamers. J Biotechnol 2000, 74, 3-4. [PubMed]
  • Wollweber L, Münster H, Hoffmann S, Siller K, Greulich KO. Early phase karyotype analysis of chromosome segregation after formation of mouse-mouse hybridomas with chromosome painting probes. Chromosome Res 2000, 8, 37-44. [PubMed]


  • Zacharias M. Comparison of molecular dynamics and harmonic mode calculations on RNA. Biopolymers 2000, 54, 547-560. [PubMed]
  • Zacharias M. Simulation of the structure and dynamics of nonhelical RNA motifs. Curr Opin Struct Biol 2000, 10, 311-317. [PubMed]
  • Zacharias M, Sklenar H. Conformational deformability of RNA: a harmonic mode analysis. Biophys J 2000, 78, 2528-2542. [PubMed]
  • Zähringer U, Moll H, Hettmann T, Knirel YA, Schäfer G. Cytochrome b558/566 from the Sulfolobus acidocaldarius has a unique Asn-linked highly branched hexasaccharide chain containing 6-sulfoquinovose. Eur J Biochem 2000, 267, 4144-4149. [PubMed]
  • Zaumseil J, Wittstock G, Bahrs S, Steinrücke P. Imaging the activity of nitrate reductase by means of a scanning electrochemical microscope. Fresenius J Anal Chem 2000, 367, 352-355. [PubMed]
  • Zhou, A, Glück B, Gothe G, Berg H. Influence of polypeptides and proteins on electrofusion of human cancer cells, Electro- and Magnetobiology 2000, 19, 321-329.
  • Zuber J, Tchernitsa OI, Hinzmann B, Schmitz AC, Grips M, Hellriegel M, Sers C, Rosenthal A, Schäfer R. A genome-wide survey of RAS transformation targets. Nat Genet 2000, 24, 144-152. [PubMed]
  • Zuurmond AM, Martien de Graaf J, Olsthoorn-Tieleman LN, van Duyl BY, Mörhle VG, Jurnak F, Mesters JR, Hilgenfeld R, Kraal B. GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu*GTP*GE2270A complexes. J Mol Biol 2000, 304, 995-1005. [PubMed]