Publications 2004

 

  • Arutyunyan R, Gebhart E, Hovhannisyan G, Greulich KO, Rapp A. Comet-FISH using peptide nucleic acid probes detects telomeric repeats in DNA damaged by bleomycin and mitomycin C proportional to general DNA damage. Mutagenesis 2004, 19, 403-408. [PubMed]
  • Bonacker D, Stoiber T, Böhm KJ, Unger E, Degen GH, Thier R, Bolt HM. Chromosomal genotoxicity of nitrobenzene and benzonitrile. Arch Toxicol 2004, 78, 49-57. [PubMed]
  • Bonacker D, Stoiber T, Wang M, Böhm KJ, Prots I, Unger E, Thier R, Bolt HM, Degen GH. Genotoxicity of inorganic mercury salts based on disturbed microtubule function. Arch Toxicol 2004, 78, 575-583. [PubMed]
  • Drexler GA, Rogge S, Beisker W, Eckardt-Schupp F, Zdzienicka MZ, Fritz E. Spontaneous homologous recombination is decreased in Rad51C-deficient hamster cells. DNA Repair (Amst) 2004, 3, 1335-1343. [PubMed]
  • Drexler GA, Wilde S, Beisker W, Ellwart J, Eckardt-Schupp F, Fritz E. The rate of extrachromosomal homologous recombination within a novel reporter plasmid is elevated in cells lacking functional ATM protein. DNA Repair (Amst) 2004, 3, 1345-1353. [PubMed]
  • Duchardt E, Richter C, Ohlenschläger O, Görlach M, Wöhnert J, Schwalbe H. Determination of the glycosidic bond angle chi in RNA from cross-correlated relaxation of CH dipolar coupling and N chemical shift anisotropy. J Am Chem Soc 2004, 126, 1962-1970. [PubMed]
  • Földes-Papp Z, Egerer R, Birch-Hirschfeld E, Striebel HM, Demel U, Tilz GP, Wutzler P. Detection of multiple human herpes viruses by DNA microarray technology. Mol Diagn 2004, 8, 1-9. [PubMed]
  • Frank C, Burkhardt C, Imhof D, Ringel J, Zschörnig O, Wieligmann K, Zacharias M, Böhmer FD. Effective dephosphorylation of Src substrates by SHP-1. J Biol Chem 2004, 279, 11375-11383. [PubMed]
  • Geller F, Reichwald K, Dempfle A, Illig T, Vollmert C, Herpertz S, Siffert W, Platzer M, Hess C, Gudermann T, Biebermann H, Wichmann HE, Schäfer H, Hinney A, Hebebrand J. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 2004, 74, 572-581. [PubMed]
  • Gerlach D, Schlott B, Schmidt KH. Cloning and expression of a sialic acid-binding lectin from the snail Cepaea hortensis. FEMS Immunol Med Microbiol 2004, 40, 215-221. [PubMed]


  • Gessner G, Zacharias M, Bechstedt S, Schönherr R, Heinemann SH. Molecular determinants for high-affinity block of human EAG potassium channels by antiarrythmic agents. Mol Pharmacol 2004, 65, 1120-1129. [PubMed]
  • Gläser C, Schulz S, Handschug K, Huse K, Birkenmeier G. Genetic and functional characteristics of the human in vivo LRP1/A2MR receptor suggested as a risk marker for Alzheimer's disease and other complex (degenerative) diseases. Neurosci Res 2004, 50, 85-101. [PubMed]
  • Glöckner G, Lehmann R, Romualdi A, Pradella S, Schulte-Spechtel U, Schilhabel M, Wilske B, Sühnel J, Platzer M. Comparative analysis of the Borrelia garinii genome. Nucleic Acids Res 2004, 32, 6038-6046. [PubMed]
  • Greulich KO. Single molecule techniques for biomedicine and pharmacology. Curr Pharm Biotechnol 2004, 5, 243-259. [PubMed]
  • Groten JP, Cassee FR, van Bladeren PJ, de Rosa C, Feron VJ, Sühnel J. Mischungen chemischer Stoffe. In: Lehrbuch der Toxikologie, (Hrsg. H. Marquardt, S. G. Schäfer), ISBN: 3804717772, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2004, Kap. 13, pp. 287-302.
  • Hettmann T, Siddiqui RA, Frey C, Santos-Silva T, Romão MJ, Diekmann S. Mutagenesis study on amino acids around the molybdenum centre of the periplasmic nitrate reductase from Ralstonia eutropha. Biochem Biophys Res Commun 2004, 320, 1211-1219. [PubMed]
  • Hiller M, Huse K, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, Platzer M. Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity. Nat Genet 2004, 36, 1255-1257. [PubMed]
  • Hogg T, Mechold U, Malke H, Cashel M, Hilgenfeld R. Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response. Cell 2004, 117, 57-68. [PubMed]
  • Hoyer C, Zander D, Fleischer S, Schilhabel M, Kroener M, Platzer M, Clos J. A Leishmania donovani gene that confers accelerated recovery from stationary phase growth arrest. Int J Parasitol 2004, 34, 803-811. [PubMed]
  • International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 2004, 431, 931-945. [PubMed]


  • Krzywinski M, Wallis J, Gösele C, Bosdet I, Chiu R, Graves T, Hummel O, Layman D, Mathewson C, Wye N, Zhu B, Albracht D, Asano J, Barber S, Brown-John M, Chan S, Chand S, Cloutier A, Davito J, Fjell C, Gaige T, Ganten D, Girn N, Guggenheimer K, Himmelbauer H, Kreitler T, Leach S, Lee D, Lehrach H, Mayo M, Mead K, Olson T, Pandoh P, Prabhu AL, Shin H, Tänzer S, Thompson J, Tsai M, Walker J, Yang G, Sekhon M, Hillier L, Zimdahl H, Marziali A, Osoegawa K, Zhao S, Siddiqui A, de Jong PJ, Warren W, Mardis E, McPherson JD, Wilson R, Hübner N, Jones S, Marra M, Schein J. Integrated and sequence-ordered BAC- and YAC-based physical maps for the rat genome. Genome Res 2004, 14, 766-779. [PubMed]
  • Lenski C, Abidi F, Meindl A, Gibson A, Platzer M, Frank Kooy R, Lubs HA, Stevenson RE, Ramser J, Schwartz CE. Novel truncating mutations in the polyglutamine tract binding protein 1 gene (PQBP1) cause Renpenning syndrome and X-linked mental retardation in another family with microcephaly. Am J Hum Genet 2004, 74, 777-780. [PubMed]
  • Leone M, Di Lello P, Ohlenschläger O, Pedone EM, Bartolucci S, Rossi M, Di Blasio B, Pedone C, Saviano M, Isernia C, Fattorusso R. Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: a molecular analysis of its reduced thermal stability. Biochemistry 2004, 43, 6043-6058. [PubMed]
  • Leppert J, Heise B, Ohlenschläger O, Görlach M, Ramachandran R. Triple resonance MAS NMR with (13C, 15N) labelled molecules: reduced dimensionality data acquisition via 13C-15N heteronuclear two-spin coherence transfer pathways. J Biomol NMR 2004, 28, 185-190. [PubMed]
  • Leppert J, Ohlenschläger O, Görlach M, Ramachandran R. Adiabatic heteronuclear decoupling in rotating solids. J Biomol NMR 2004, 29, 319-324. [PubMed]
  • Leppert J, Ohlenschläger O, Görlach M, Ramachandran R. Adiabatic TOBSY in rotating solids. J Biomol NMR 2004, 29, 167-173. [PubMed]
  • Leppert J, Ohlenschläger O, Görlach M, Ramachandran R. RFDR with adiabatic inversion pulses: application to internuclear distance measurements. J Biomol NMR 2004, 28, 229-233. [PubMed]
  • Leppert J, Urbinati CR, Häfner S, Ohlenschläger O, Swanson MS, Görlach M, Ramachandran R. Identification of NH...N hydrogen bonds by magic angle spinning solid state NMR in a double-stranded RNA associated with myotonic dystrophy. Nucleic Acids Res 2004, 32, 1177-1183. [PubMed]
  • Monie TP, Greatorex JS, Zacharias M, Lever AM. The human T-cell lymphotopic virus type-1 dimerisation initiation site forms a hairpin loop unlike previously characterized retroviral dimerisation motifs. Biochemistry 2004, 43, 6085-6090. [PubMed]
  • Ohlenschläger O, Wöhnert J, Bucci E, Seitz S, Häfner S, Ramachandran R, Zell R, Görlach M. The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C. Structure 2004, 12, 237-248. [PubMed]


  • Piel J, Hui D, Wen G, Butzke D, Platzer M, Fusetani N, Matsunaga S. Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei. Proc Natl Acad Sci U S A 2004, 101, 16222-16227. [PubMed]
  • Piel J, Wen G, Platzer M, Hui D. Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase. Chembiochem 2004, 5, 93-98. [PubMed]
  • Randazzo A, Esposito V, Ohlenschläger O, Ramachandran R, Mayola L. NMR solution structure of a parallel LNA quadruplex. Nucleic Acids Res 2004, 32, 3083-3092. [PubMed]
  • Riedel K, Leppert J, Häfner S, Ohlenschläger O, Görlach M, Ramachandran R. Homonuclear chemical shift correlation in rotating solids via RNnu n symmetry-based adiabatic RF pulse schemes. J Biomol NMR 2004, 30, 389-395. [PubMed]
  • Riedel K, Leppert J, Ohlenschläger O, Görlach M, Ramachandran R. Heteronuclear decoupling in rotating solids via symmetry-based adiabatic RF pulse schemes. Chem Phys Lett 2004, 395, 356-361.
  • Riemann RN, Zacharias M. Reversible scaling of dihedral angle barriers during molecular dynamics to improve structure prediction of cyclic peptides. J Pept Res 2004, 63, 354-364. [PubMed]
  • Rudeschko O, Machnik A, Dörfelt H, Kaatz HH, Schlott B, Kinne RW. A novel inhalation allergen present in the working environment of beekeepers. Allergy 2004, 59, 332-337. [PubMed]
  • Schmiedeberg L, Weisshart K, Diekmann S, Meyer Zu Hoerste G, Hemmerich P. High- and low-mobility populations of HP1 in heterochromatin of mammalian cells. Mol Biol Cell 2004, 15, 2819-2833. [PubMed]
  • Schönecker B, Zheldakova T, Lange C, Günther W, Görls H, Bohl M. Intramolecular gamma-hydroxylations of nonactivated C-H bonds with copper complexes and molecular oxygen. Chemistry 2004, 10, 6029-6042. [PubMed]


  • Sinnreich O, Kratzsch J, Reichenbach A, Gläser C, Huse K, Birkenmeier G. Plasma levels of transforming growth factor-1beta and alpha2-macroglobulin before and after radical prostatectomy: association to clinicopathological parameters. Prostate 2004, 61, 201-208. [PubMed]
  • Søe K, Rockstroh A, Schache P, Grosse F. The human topoisomerase I damage response plays a role in apoptosis. DNA Repair (Amst) 2004, 3 , 387-393. [PubMed]
  • Sponner A, Unger E, Grosse F, Weisshart K. Conserved C-termini of spidroins are secreted by the major ampullate glands and retained in the silk thread. Biomacromolecules 2004, 5, 840-845. [PubMed]
  • Stoiber T, Bonacker D, Böhm KJ, Bolt HM, Thier R, Degen GH, Unger E. Disturbed microtubule function and induction of micronuclei by chelate complexes of mercury(II). Mutat Res 2004, 563, 97-106. [PubMed]
  • Stoiber T, Degen GH, Bolt HM, Unger E. Interaction of mercury(II) with the microtubule cytoskeleton in IMR-32 neuroblastoma cells. Toxicol Lett 2004, 151, 99-104. [PubMed]
  • Stoldt M, Kupce E, Rehm BH, Görlach M. Backbone resonance assignment of an aminoglycoside-3'-phosphotransferase type IIa. J Biomol NMR 2004, 28, 93-94. [PubMed]
  • Striebel HM, Birch-Hirschfeld E, Egerer R, Földes-Papp Z, Tilz GP, Stelzner A. Enhancing sensitivity of human herpes virus diagnosis with DNA microarrays using dendrimers. Exp Mol Pathol 2004, 77, 89-97. [PubMed]
  • Striebel HM, Schellenberg P, Grigaravicius P, Greulich KO. Readout of protein microarrays using intrinsic time resolved UV fluorescence for label-free detection. Proteomics 2004, 4, 1703-1711. [PubMed]
  • Szymoszek A, Zacharias M. Reduced protein model as a tool in the homology modeling. Internet Electron J Mol Des 2004, November 29 - December 12.
  • Villescas-Diaz G, Zacharias M. Efficient search on energy minima for structure prediction of nucleic acid motifs. J Biomol Struct Dyn 2004, 22, 355-364. [PubMed]


  • Wang HJ, Geller F, Dempfle A, Schäuble N, Friedel S, Lichtner P, Fontenla-Horro F, Wudy S, Hagemann S, Gortner L, Huse K, Remschmidt H, Bettecken T, Meitinger T, Schäfer H, Hebebrand J, Hinney A. Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature. J Clin Endocrinol Metab 2004, 89, 157-162. [PubMed]
  • Watanabe H, Fujiyama A, Hattori M, Taylor TD, Toyoda A, Kuroki Y, Noguchi H, BenKahla A, Lehrach H, Sudbrak R, Kube M, Taenzer S, Galgoczy P, Platzer M, Scharfe M, Nordsiek G, Blöcker H, Hellmann I, Khaitovich P, Pääbo S, Reinhardt R, Zheng HJ, Zhang XL, Zhu GF, Wang BF, Fu G, Ren SX, Zhao GP, Chen Z, Lee YS, Cheong JE, Choi SH, Wu KM, Liu TT, Hsiao KJ, Tsai SF, Kim CG, OOta S, Kitano T, Kohara Y, Saitou N, Park HS, Wang SY, Yaspo ML, Sakaki Y. DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature 2004, 429, 382-388. [PubMed]
  • Wieland G, Orthaus S, Ohndorf S, Diekmann S, Hemmerich P. Functional complementation of human centromere protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae. Mol Cell Biol 2004, 24, 6620-6630. [PubMed]
  • Zacharias M. Rapid protein-ligand docking using soft modes from molecular dynamics simulations to account for protein deformability: binding of FK506 to FKBP. Proteins 2004, 54, 759-767. [PubMed]
  • Zell R, Markgraf R, Schmidtke M, Görlach M, Stelzner A, Henke A, Sigusch HH, Glück B. Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice. Med Microbiol Immunol 2004, 193, 91-100. [PubMed]
  • Zhang S, Grosse F. Acta Biochim Biophys Sin (Shanghai). 2004, 36, 177-183. Multiple functions of nuclear DNA helicase II (RNA helicase A) in nucleic acid metabolism. [PubMed]
  • Zhang S, Hemmerich P, Grosse F. Nucleolar localization of the human telomeric repeat binding factor 2 (TRF2). J Cell Sci 2004, 117, 3935-3945. [PubMed]
  • Zhang S, Köhler C, Hemmerich P, Grosse F. Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus. Exp Cell Res 2004, 293, 248-258. [PubMed]
  • Zhang S, Schlott B, Görlach M, Grosse F. DNA-dependent protein kinase (DNA-PK) phosphorylates nuclear DNA helicase II/RNA helicase A and hnRNP proteins in an RNA-dependent manner. Nucleic Acids Res 2004, 32, 1-10. [PubMed]