Biocomputing Group: Leibniz Institute for Age Research

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Parallel-stranded DNA-quadruplex of the Tetrahymena telomeric sequence d(T-T-G-G-G-T) [PDB code: 139d]. One of the G-tetrads is highlighted.

We have explored the properties of base tetrads by means of quantum-chemical calculations, see for example :

M. Meyer, J. Sühnel:
Base Polyad Motifs in Nucleic Acids - Biological Significance, Occurrence in Three-Dimensional Experimental Structures and Computational Studies. In: Computational Chemistry: Reviews of Current Trends, Vol. 8, (Ed. J. Leszczynski),World Scientific (ISBN 981-238-702-1), 2003, chapter 4, pp. 161-208.

Further papers on this topic can be found on our list of publications.

Enlarge image

Cover page of the February 25, 2002 Issue of Biopolymers (Nucleic Acid Sciences)

referring to the article: J. Sühnel, Biopolymers 2002, 61, 31-51. Beyond nucleic acid base pairs: From triads to heptads.

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