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Most experimental work is done with one or
a few tissue types. Therefore it is never clear, how general statements
derived from such experiments are. In order to decide whether for
example the overexpression of a given gene is a feature of cancer, an
overview of cancer -
relevant molecules in
essentially
all cancers need to be given. We use NIH’s database dbEST, which
provides data on the
expression
of essentially all human genes in 51 normal tissues and their cancers.
We
selected 24 of these tissues, for which the statistical quality of the
data is
already sufficient to obtain robust results. The 24 tissues represent
appox. 70
% of all clinical cancer cases i ) The Warburg effect occurs only in selected tissues. This is the reason, why doubts had come up whether the Warburg effect is real at all. The study solves that point. Altenberg and Greulich, PDF 2004 GENOMICS 84 1014 - 1020 ii) Among the 20 000 human genes only approx. 50 are upregulated in the majority of cancers. All other genes are upregulated only in a few selected cancer tissues Altenberg, Gemuend and Greulich 2006 PROTEOMICS 6 67 - 71
iv)
The Database dbEST Correctly Predicts Gene Expression in Colon Cancer
Patients 2008 Radeva M,
Hofmann T, Altenberg B, Mothes H, Richter KK, Pool-Zobel B, Greulich
KO PDF 2008 CURR
PHARM BIOT 2008, 9 509 - 514
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